How to Use Peptides: Serums, Creams and Rinse-Off Pads

The best peptide routine is usually the one with the fewest moving parts. Add one product at a time, keep your sunscreen routine intact, and do not change several actives in the same week.

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First, check whether it is a serum, cream or rinse-off peel

The product format changes the instructions. A leave-on serum and an exfoliating pad do not belong in the same routine step simply because both mention peptides. Read the full product name and directions before deciding when to apply it.

Peter Thomas Roth peel pads: rinse off, do not leave on

Peptide Skinjection Exfoliating Peel Pads are an acid exfoliant with amino acids, not a leave-on peptide serum or a basic hydrating toner pad. Peter Thomas Roth describes a 20% exfoliating complex. Its directions say to start 1–3 times weekly, leave on for 1–3 minutes, then rinse thoroughly with water and pat dry. Follow your package instructions; do not interpret the peptide name as a reason to skip rinsing.

A discount is not a reason to add another exfoliant to a routine that is already uncomfortable. If you use prescription skincare or are unsure how an acid peel fits your routine, ask your clinician before combining products. Stop a product that causes persistent burning or a rash; do not try to push through irritation.

Current peel-pad offer and cost per pad

Checked October 18, 2026: Peter Thomas Roth Peptide Skinjection Exfoliating Peel Pads, 60 count, ASIN B00YP3O270, were $39.47 for a one-time purchase versus a displayed $48 list price—shown as 18% off. They were in stock, sold and shipped by Amazon.com. That is about $0.66 per pad before tax. The separate Subscribe & Save offer requires a subscription and is not the price quoted here. No confirmed end date was shown. Verify the exact jar and final total; prices can change.

Check Peter Thomas Roth Peptide Skinjection Peel Pads, 60 count

Read Peter Thomas Roth’s full ingredients and rinse-off directions

The leave-on routine below is not the peel-pad routine

A simple morning routine

Cleanse if needed, apply a peptide serum if you use one, follow with moisturizer, then use broad-spectrum sunscreen. The point is consistency and comfort, not squeezing every possible active into one routine.

A simple evening routine

Cleanse, use the peptide product according to its label, then moisturize. If you already use a retinoid or exfoliating acid, introduce the peptide product on alternate nights first so it is easier to identify what causes irritation.

Patch testing and troubleshooting

Try a small amount on a discreet area according to the product directions. Stop use if you develop a persistent rash, swelling, or significant burning. A gentle routine with moisturizer and sunscreen is a more sensible baseline than pushing through irritation.

Use the peptides in skincare hub for product-format guidance.